Detalhe da pesquisa
1.
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.
Immunity
; 44(3): 609-621, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26944201
2.
Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic.
Proc Natl Acad Sci U S A
; 118(26)2021 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34172583
3.
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Nature
; 501(7466): 232-6, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23934108
4.
Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.
J Biol Chem
; 292(35): 14311-14324, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28655764
5.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27479743
6.
Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.
Proteomics
; 16(14): 1992-7, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282143
7.
Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms.
Proteomics
; 16(14): 1998-2004, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27273156
8.
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Nature
; 464(7287): 431-5, 2010 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20130576
9.
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.
Proc Natl Acad Sci U S A
; 110(48): 19426-31, 2013 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24218548
10.
PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition.
J Pathol
; 234(4): 502-13, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25074413
11.
Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.
Mol Cell Proteomics
; 12(8): 2070-80, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23608596
12.
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
Proc Natl Acad Sci U S A
; 108(17): 7177-82, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21482786
13.
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase ß isoform.
Bioorg Med Chem Lett
; 23(9): 2606-13, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23540645
14.
Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome.
Nat Genet
; 36(3): 288-92, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-14981519
15.
Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.
Drug Metab Dispos
; 40(5): 919-27, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22315332
16.
A Probody T Cell-Engaging Bispecific Antibody Targeting EGFR and CD3 Inhibits Colon Cancer Growth with Limited Toxicity.
Cancer Res
; 82(22): 4288-4298, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36112781
17.
Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate.
Mol Cancer Ther
; 21(8): 1326-1336, 2022 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35666803
18.
Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents.
Cancer Immunol Res
; 9(12): 1451-1464, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34635485
19.
Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.
Drug Metab Dispos
; 38(9): 1436-42, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20538720
20.
Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor.
Xenobiotica
; 40(11): 751-62, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20836753